Bicarbonate Dialysis Using a Single Concentrate

Dual-concentrate bicarbonate-based hemodialysis: know your buffers.

Bicarbonate/lactate- and bicarbonate-buffered peritoneal dialysis fluids improve ex vivo peritoneal macrophage TNFalpha secretion.

Peritoneal macrophage (PMO) function was examined ex vivo after their in vivo exposure to either acidic, lactate-buffered solutions (PD4; 40 mM lactate, pH 5.2), bicarbonate/lactate-buffered solution (TBL; 25 mM/15 mM bicarbonate/lactate, pH 7.3), or bicarbonate-buffered solution (TB; 38 mM bicarbonate, pH 7.3), containing either 1.36 or 3.86% glucose. Initial experiments demonstrated that tumo...

Comparison between bicarbonate/lactate and standard lactate dialysis solution in peritoneal transport and ultrafiltration: a prospective, crossover single-dwell study.

OBJECTIVE It has been proposed that biocompatible bicarbonate/lactate based (Bic/Lac), physiologic-pH peritoneal dialysis (PD) solutions will be beneficial in long-term PD. However, we do not yet have detailed knowledge concerning the comparative physiology of buffer transport for these new solutions and their impact on underlying peritoneal transport of solutes and ultrafiltration (UF). The pu...

Improved in vitro biocompatibility of bicarbonate-buffered peritoneal dialysis fluid.

BACKGROUND Conventional peritoneal dialysis fluids (PDFs) have been shown to damage the mesothelial layer and are associated with the development of peritoneal fibrosis and neoangiogenesis. New-generation PDFs have therefore been developed with physiological pH and reduced levels of glucose degradation products (GDPs), precursors of advanced glycation end products (AGEs). In this work, we evalu...

Single needle dialysis.

Home Dialysis Training Center Division of Artificial Organs University of Utah Salt Lake City, Utah 84112 Introduction Access to the bloodstream has alway been a problem in hemodialysis. The presently preferred method is a surgically created arteriovenous fistula, as described by Brescia and co-workers in 1966. However, the use of the A-V fistula is limited. Frequent venipunctures with large bo...